The 'Grey's Anatomy' alum revealed his reallife ALS diagnosis in April. Eric Dane books new guest role playing an ALS patient

The 'Grey's Anatomy' alum revealed his real-life ALS diagnosis in April.

Eric Dane books new guest role playing an ALS patient

The 'Grey's Anatomy' alum revealed his real-life ALS diagnosis in April.

By Mekishana Pierre

Mekishana Pierre

Mekishana Pierre is a news writer at **. She has been working at EW since 2025. Her work has previously appeared on *Entertainment Tonight* and Popsugar.

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October 20, 2025 2:00 p.m. ET

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Eric Dane and Zachary Quinto in 'Brilliant Minds'. Credit:

Pief Weyman/NBC

Eric Dane is bringing his real-life experience as someone diagnosed with ALS to work.

The 52-year-old actor, who revealed his ALS diagnosis in April, will guest-star on the second season of NBC's medical drama series *Brilliant Minds*. The series follows Dr. Wolf (Zachary Quinto) and his team at Bronx General as they delve into medical mysteries of the mind. Ultimately, they come face to face with the question: Who deserves care? **

Dane will appear in this season's ninth episode and play Matthew, a heroic firefighter who struggles to share his ALS diagnosis with his family.**

Zachary Quinto and Eric Dane in 'Brilliant Minds'.

Pief Weyman/NBC

The new role comes amid Dane's public campaign to find federal funding for research on the incurable neurological disease.**

ALS — or amyotrophic lateral sclerosis — is a progressive nervous system disease that affects cells in the brain and spinal cord, causing loss of muscle control. Over time, it impairs patients' ability to breathe, speak, and move, leading to full paralysis, according to the Mayo Clinic. It is 100 percent fatal, and there is no cure.

Since Dane disclosed his diagnosis in April, the disease has visibly affected the star's ability to move freely.

The *Euphoria* star — who has been married to actress and model Rebecca Gayheart since 2004, and shares daughters Billie Beatrice, 15, and Georgia Geraldine, 13, with her — has spoken candidly about the journey and his desire to fight with all his might to be there for his family as long as he can.

Eric Dane's daughters are 'really suffering' after his ALS diagnosis, wife Rebecca Gayheart says: 'Heartbreaking'

Eric Dane explains why he missed 'Grey's Anatomy' reunion at Emmys: 'ALS is a nasty disease'

In June, Dane told Diane Sawyer that he has lost function in his right arm while his left one has been getting weaker. "I feel like maybe a couple more months and I won't have my left hand either," Dane said. "It's sobering."

In September, a noticeably less mobile Dane joined doctors and representatives from the I Am ALS organization for a discussion with California Congressman Eric Swalwell about investing in innovative treatments to ensure access to quality care for those diagnosed with ALS, as well as their families and researchers.

"I wanna ring every bell," Dane told Swalwell in a TikTok video shared by the politician from their meeting in Washington, D.C. "I have two daughters at home. I wanna see them graduate college, get married, maybe have grandkids."

"I wanna be there for all that. So, I'm gonna fight until the last breath on this one," the *Grey's Anatomy *alum added.

***Get your daily dose of entertainment news, celebrity updates, and what to watch with our EW Dispatch newsletter.***

The actor is partnering with the organization I Am ALS for Push for Progress, a fundraising initiative that hopes to raise $1 billion for ALS research in three years to help give "promising treatments to thousands of patients like me, and finally, finally, push towards ending this disease," Dane said in a video on social media calling for further ALS research. "There's so much more to learn, more to do, and we have to do it now."

*Brilliant Minds* airs Mondays at 10 p.m. on NBC, and next day on Peacock. **

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